Modification of single sodium channels by the insecticide tetramethrin.

Abstract

(+)-trans-Tetramethrin, a pyrethroid insecticide, markedly prolongs the open time of single sodium channels recorded by the gigaohm-seal voltage clamp technique in a membrane patch excised from the N1E-115 neuroblastoma cell. Single channel conductance is not altered by tetramethrin. The modification by tetramethrin occurs in an all-or-none manner in a population of sodium channels. The observed tetramethrin-induced modification of single sodium channels is compatible with previous sodium current data from axons.

• Authors: D Yamamoto, F N Quandt, T Narahashi
• Journal: Brain research (Brain Res) Vol. 274 Issue 2 Pg. 344-9 (Sep 12 1983) ISSN: 0006-8993 [Print] Netherlands
• PMID: 6313121 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Batrachotoxins
• Ion Channels
• Pyrethrins
• Sodium
• tetramethrin

Topics

• Animals
• Batrachotoxins (pharmacology)
• Cell Line
• Ion Channels (drug effects)
• Mice
• Neuroblastoma
• Pyrethrins (pharmacology)
• Sodium (metabolism)