HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

In vivo antiviral effect of 9-(2-hydroxyethoxymethyl) guanine on experimental infection of chum salmon (Oncorhynchus keta) fry with Oncorhynchus masou virus (OMV).

Abstract
The therapeutic efficacy of 9-(2-hydroxyethoxymethyl) guanine (Acyclovir, ACV) was evaluated using Oncorhynchus masou virus (OMV) and chum salmon fry. The fish, which were experimentally infected with OMV, were treated with ACV either orally or by the immersion method. Daily immersion of fish into ACV solution (25 microgram/ml, 30 min/day, 15 times) reduced mortality of the infected fish. Oral administration of the drug (25 microgram/fish per day, 60 times) did not affect survival of the chum salmon. On the contrary, the group administered 5-iodo-2'-deoxyuridine (IUdR) by the oral route showed a higher survival than the ACV-administered group. This suggested that an effective level of ACV was not maintained in fish given the drug by the oral route. Daily immersion of infected fish into ACV solution (25 microgram/ml, 30 min/day, 60 times) considerably suppressed the development of tumors induced by OMV.
AuthorsT Kimura, S Suzuki, M Yoshimizu
JournalAntiviral research (Antiviral Res) Vol. 3 Issue 2 Pg. 103-8 (Aug 1983) ISSN: 0166-3542 [Print] NETHERLANDS
PMID6312875 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Acyclovir
Topics
  • Acyclovir (administration & dosage, therapeutic use)
  • Animals
  • Fish Diseases (drug therapy)
  • Herpesviridae Infections (drug therapy, veterinary)
  • Neoplasms (etiology, veterinary)
  • Salmon (microbiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: