Abstract |
In treating a patient with a malignant eccrine poroma, in-vitro studies suggested resistance to dactinomycin and doxorubicin. A trial of weekly 5-fluorouracil produced no response. Likewise, a cycle of cisplatinum and cytarabine was associated with continued progression of the disease. Use of 13-cis retinoic acid induced a partial remission that lasted for 8 weeks with minimal toxicity. The mechanism of action is not known, but local tumor necrosis with sparing of the adjacent normal tissue suggests high specificity.
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Authors | M Roach 3rd |
Journal | Annals of internal medicine
(Ann Intern Med)
Vol. 99
Issue 4
Pg. 486-8
(Oct 1983)
ISSN: 0003-4819 [Print] United States |
PMID | 6312862
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antineoplastic Agents
- Tretinoin
- Isotretinoin
|
Topics |
- Adenoma, Sweat Gland
(drug therapy, surgery)
- Antineoplastic Agents
(administration & dosage)
- Drug Therapy, Combination
- Humans
- Isotretinoin
- Lung Neoplasms
(secondary)
- Male
- Middle Aged
- Neoplasm Invasiveness
- Neoplasm Recurrence, Local
(drug therapy)
- Neoplasms, Multiple Primary
- Sweat Gland Neoplasms
(drug therapy, surgery)
- Thigh
- Tretinoin
(therapeutic use)
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