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High dose intravenous IgG reduces platelet associated immunoglobulins and complement in idiopathic thrombocytopenic purpura.

Abstract
4 children with idiopathic thrombocytopenic purpura were treated with high dose i.v. IgG. Platelet associated immunoproteins were determined with an Elisa technique. Platelet counts increased in all patients, while simultaneously platelet associated IgG, IgA, IgM, C3 and C4 decreased. Serum antiplatelet antibody increased during treatment suggesting that administration of high doses of IgG interferes with the binding of antiplatelet antibody.
AuthorsJ Winiarski, A Kreuger, J Ejderhamn, G Holm
JournalScandinavian journal of haematology (Scand J Haematol) Vol. 31 Issue 4 Pg. 342-8 (Oct 1983) ISSN: 0036-553X [Print] Denmark
PMID6312557 (Publication Type: Journal Article)
Chemical References
  • Complement C3
  • Complement C4
  • Immunoglobulin A
  • Immunoglobulin G
  • Immunoglobulin M
Topics
  • Blood Platelets (immunology)
  • Child
  • Complement C3 (analysis)
  • Complement C4 (analysis)
  • Cytomegalovirus Infections (complications, immunology, therapy)
  • Dose-Response Relationship, Immunologic
  • Female
  • Humans
  • Immunoglobulin A (analysis)
  • Immunoglobulin G (administration & dosage, analysis)
  • Immunoglobulin M (analysis)
  • Infant
  • Purpura, Thrombocytopenic (immunology, therapy)
  • Thrombocytopenia (complications, immunology, therapy)

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