Abstract |
4 children with idiopathic thrombocytopenic purpura were treated with high dose i.v. IgG. Platelet associated immunoproteins were determined with an Elisa technique. Platelet counts increased in all patients, while simultaneously platelet associated IgG, IgA, IgM, C3 and C4 decreased. Serum antiplatelet antibody increased during treatment suggesting that administration of high doses of IgG interferes with the binding of antiplatelet antibody.
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Authors | J Winiarski, A Kreuger, J Ejderhamn, G Holm |
Journal | Scandinavian journal of haematology
(Scand J Haematol)
Vol. 31
Issue 4
Pg. 342-8
(Oct 1983)
ISSN: 0036-553X [Print] Denmark |
PMID | 6312557
(Publication Type: Journal Article)
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Chemical References |
- Complement C3
- Complement C4
- Immunoglobulin A
- Immunoglobulin G
- Immunoglobulin M
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Topics |
- Blood Platelets
(immunology)
- Child
- Complement C3
(analysis)
- Complement C4
(analysis)
- Cytomegalovirus Infections
(complications, immunology, therapy)
- Dose-Response Relationship, Immunologic
- Female
- Humans
- Immunoglobulin A
(analysis)
- Immunoglobulin G
(administration & dosage, analysis)
- Immunoglobulin M
(analysis)
- Infant
- Purpura, Thrombocytopenic
(immunology, therapy)
- Thrombocytopenia
(complications, immunology, therapy)
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