Anticonvulsant action in the photosensitive baboon, Papio papio, of a novel beta-carboline derivative, ZK 91296.

Abstract

The anticonvulsant action of ethyl-5-benzyloxy-4-methoxymethyl-beta-carboline-3-carboxylate (ZK 91296) has been studied in Senegalese baboons, Papio papio, with photosensitive epilepsy. Myoclonic and paroxysmal electroencephalographic responses to stroboscopic stimulation are diminished or abolished for 2-4 h after ZK 91296, 0.25-4 mg/kg, i.v. Radioreceptor assay of plasma ZK 91296 indicates rapid clearance (t 1/2 alpha, 5-20 min and beta, 60-90 min). In this model of generalised epilepsy ZK 91296 is similar to diazepam in potency but has a longer duration of action.

• Authors: B S Meldrum, M C Evans, C Braestrup
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 91 Issue 2-3 Pg. 255-9 (Jul 22 1983) ISSN: 0014-2999 [Print] Netherlands
• PMID: 6311579 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anticonvulsants
• Carbolines
• Indoles
• Receptors, Cell Surface
• Receptors, GABA-A
• ZK 91296

Topics

• Animals
• Anticonvulsants (metabolism, pharmacology)
• Carbolines (metabolism, pharmacology, therapeutic use)
• Electroencephalography
• Indoles (pharmacology)
• Kinetics
• Papio
• Photic Stimulation
• Receptors, Cell Surface (metabolism)
• Receptors, GABA-A
• Seizures (drug therapy)