Abstract |
Twenty patients with small cell carcinoma of the lung resistant to primary therapy, or relapsing after an objective response to initial treatment, were treated with vinblastine plus high-dose cisplatin chemotherapy. One patient achieved a partial remission lasting 4 months, while 19 patients had no objective response to this regimen. The median survival from the time of disease progression to death was 2.5 months (range, 1-7), with an overall median survival of 13 months (range, 5-31; diagnosis to death). In our patients, vinblastine plus cisplatin given as salvage therapy did not produce a significant response rate or survival prolongation.
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Authors | S B Newman, J D Bitran, P C Hoffman, V Raghaven, T R DeMeester, H M Golomb |
Journal | Cancer treatment reports
(Cancer Treat Rep)
Vol. 67
Issue 9
Pg. 831-2
(Sep 1983)
ISSN: 0361-5960 [Print] United States |
PMID | 6309381
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Carcinoma, Small Cell
(drug therapy)
- Cisplatin
(administration & dosage, adverse effects)
- Drug Therapy, Combination
- Female
- Humans
- Lung Neoplasms
(drug therapy)
- Male
- Middle Aged
- Vinblastine
(administration & dosage, adverse effects)
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