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Expression of intermediate filaments in normal ovaries and ovarian epithelial, sex cord-stromal, and germinal tumors.

Abstract
The presence of different types of intermediate filaments (IMF) was studied in normal ovarial tissue and in ovarian tumors. The coelomic epithelium contained both prekeratin and vimentin, but the graafian follicle cells and stromal cells contained only vimentin. In normal ovaries, desmin positivity was confined to the arterial walls. Tumors derived from surface epithelium, including Brenner tumors, expressed prekeratin in the epithelial cells, whereas sex cord-stromal tumors showed only vimentin-type IMF. Germinal tumors also showed only vimentin-type IMF, whereas differentiated teratomas expressed the IMF of the corresponding differentiation line, as recognized by light microscopy. Thus, the skin, skin appendages, and other epithelial components of dermoid cysts showed prekeratin; mesenchymal components showed vimentin (but smooth muscle cells, desmin), and glial-like areas showed glial fibrillary acidic protein. The results suggest that expression of IMF in ovarian tumors corresponds to the filament expression of the parental tissues and that the typing of IMF can be used in the differential diagnosis between ovarian tumors of different histogenesis.
AuthorsM Miettinen, V P Lehto, I Virtanen
JournalInternational journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists (Int J Gynecol Pathol) Vol. 2 Issue 1 Pg. 64-71 ( 1983) ISSN: 0277-1691 [Print] United States
PMID6307907 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies
  • Intermediate Filament Proteins
Topics
  • Antibodies
  • Cytoskeleton (ultrastructure)
  • Female
  • Fluorescent Antibody Technique
  • Humans
  • Intermediate Filament Proteins (analysis, immunology)
  • Microscopy, Electron
  • Neoplasms, Germ Cell and Embryonal (ultrastructure)
  • Neoplasms, Glandular and Epithelial (ultrastructure)
  • Ovarian Neoplasms (ultrastructure)
  • Ovary (ultrastructure)

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