Abstract |
The possible protective effects of 30 and 180 mM mannitol added to the extracellular medium were studied in Ehrlich ascites tumor cells (EATC) injured by the nonpenetrating mercurial p-chloromercuribenzenesulfonic acid ( PCMBS) or by anoxia. Protection was provided with 180 mM mannitol as observed by vital dye uptake, cell volume determinations, and electron microscopy studies in cells incubated for 1 hr in 1 mM PCMBS; however, no protection was observed after 2 and 4 hr. EATC injured by anoxia were not protected by 180 mM mannitol nor did 30 mM offer protection to cells following injury with either PCMBS or anoxia.
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Authors | K U Laiho, I K Berezesky, B F Trump |
Journal | Experimental and molecular pathology
(Exp Mol Pathol)
Vol. 39
Issue 1
Pg. 110-28
(Aug 1983)
ISSN: 0014-4800 [Print] Netherlands |
PMID | 6307742
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Aniline Compounds
- Buffers
- Phenylmercury Compounds
- Mannitol
- 4-Chloromercuribenzenesulfonate
- nigrosin
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Topics |
- 4-Chloromercuribenzenesulfonate
(administration & dosage)
- Aniline Compounds
- Animals
- Buffers
- Carcinoma, Ehrlich Tumor
(chemically induced, drug therapy, ultrastructure)
- Cell Membrane Permeability
(drug effects)
- Cell Transformation, Neoplastic
(drug effects, ultrastructure)
- Dose-Response Relationship, Drug
- Hydrogen-Ion Concentration
- Hypoxia
(complications)
- Mannitol
(administration & dosage)
- Mice
- Phenylmercury Compounds
(administration & dosage)
- Vacuoles
(drug effects, ultrastructure)
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