| Abstract | In 1976, a 61-year-old female was diagnosed as malignant cystosarcoma phyllodes, and she was admitted to the hospital for chemotherapy. She was started receiving the combination chemotherapy consisting of adriamycin. 60 mg/3-week, mitomycin C, 1 mg/week, 5-Fluorouracil, 175 mg/week, and citosine arabinoside, 10 mg/week. The initial ECG revealed incomplete right bundle branch block pattern. After the first 60 mg administration of adriamycin, the ECG showed non-specific ST-T changes in addition to I.R.B.B.B. pattern. At the second 60 mg administration of adriamycin, the ECG returned to normal. After the administration of adriamycin, the ECG showed the same ST-T changes again which were seen at the first adriamycin treatment. The same phenomenon was observed at the third adriamycin treatment. In this case, there was a reproducible coincidence between the administration of adriamycin and the occurrence of non-specific changes on ECG; the fore a possibility of adriamycin cardiotoxicity was strongly suggested. |
| Authors | K Okuma, K Ota |
| Journal | Gan to kagaku ryoho. Cancer & chemotherapy
(Gan To Kagaku Ryoho)
Vol. 9
Issue 5
Pg. 936-41
(May 1982)
ISSN: 0385-0684 JAPAN |
| PMID | 6307186
(Publication Type: Case Reports, English Abstract, Journal Article)
|
| Chemical References |
- Mitomycins
- Doxorubicin
- Mitomycin
- Fluorouracil
|
| Topics |
- Breast Neoplasms
(drug therapy)
- Doxorubicin
(adverse effects)
- Electrocardiography
- Female
- Fluorouracil
(administration & dosage)
- Heart
(drug effects)
- Humans
- Middle Aged
- Mitomycin
- Mitomycins
(administration & dosage)
- Phyllodes Tumor
(drug therapy)
|
