Blocked 5'-termini in the fragments of chromosomal DNA produced in cells exposed to the antitumor drug 4'-[(9-acridinyl)-amino]methanesulphon-m-anisidide (mAMSA).

Abstract	Comparison of the sensitivity of DNA isolated from untreated and mAMSA-treated PY815 mouse mastocytoma cells to hydrolysis by E.coli 3'-exonuclease III and phage lambda or phage T7 5'-exonucleases show that the fragments of chromosomal DNA produced by mAMSA treatment have free 3'-OH termini and blocked 5'-termini.
Authors	B Marshall, R K Ralph, R Hancock
Journal	Nucleic acids research (Nucleic Acids Res) Vol. 11 Issue 12 Pg. 4251-6 (Jun 25 1983) ISSN: 0305-1048 [Print] England
PMID	6306581 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Aminoacridines Antineoplastic Agents Amsacrine DNA Exodeoxyribonucleases exodeoxyribonuclease III Phosphoric Diester Hydrolases Phosphodiesterase I
Topics	Aminoacridines (pharmacology) Amsacrine Animals Antineoplastic Agents (pharmacology) Base Sequence DNA (analysis) Escherichia coli (enzymology) Exodeoxyribonucleases (metabolism) Hydrolysis Mast-Cell Sarcoma (genetics) Mice Phosphodiesterase I Phosphoric Diester Hydrolases (metabolism) T-Phages (enzymology)

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