Cimetidine-resistant Zollinger-Ellison syndrome: successful management with ranitidine.

Abstract

In a patient with the Zollinger-Ellison syndrome who had undergone vagotomy, pyloroplasty and, later, gastrojejunostomy, epigastric pain and stomal ulceration recurred despite the use of high doses (2700 mg/d) of cimetidine. Ranitidine, a new histamine H2-receptor antagonist, reversed all symptoms and healed the stomal ulcer without side effects, thus obviating the need for further surgery. Ranitidine may prove to be the drug of choice in the medical management of patients with the Zollinger-Ellison syndrome.

• Authors: F M Habal, S J Soldin, G R Greenberg
• Journal: Canadian Medical Association journal (Can Med Assoc J) Vol. 129 Issue 3 Pg. 256-8 (Aug 01 1983) ISSN: 0008-4409 [Print] Canada
• PMID: 6305470 (Publication Type: Case Reports, Comparative Study, Journal Article)

Chemical References

• Anti-Ulcer Agents
• Furans
• Cimetidine
• Ranitidine

Topics

• Adult
• Anti-Ulcer Agents (therapeutic use)
• Cimetidine (therapeutic use)
• Furans (therapeutic use)
• Humans
• Male
• Ranitidine
• Zollinger-Ellison Syndrome (drug therapy)