Cimetidine-resistant Zollinger-Ellison syndrome: successful management with ranitidine.

In a patient with the Zollinger-Ellison syndrome who had undergone vagotomy, pyloroplasty and, later, gastrojejunostomy, epigastric pain and stomal ulceration recurred despite the use of high doses (2700 mg/d) of cimetidine. Ranitidine, a new histamine H2-receptor antagonist, reversed all symptoms and healed the stomal ulcer without side effects, thus obviating the need for further surgery. Ranitidine may prove to be the drug of choice in the medical management of patients with the Zollinger-Ellison syndrome.
AuthorsF M Habal, S J Soldin, G R Greenberg
JournalCanadian Medical Association journal (Can Med Assoc J) Vol. 129 Issue 3 Pg. 256-8 (Aug 1 1983) ISSN: 0008-4409 [Print] CANADA
PMID6305470 (Publication Type: Case Reports, Comparative Study, Journal Article)
Chemical References
  • Anti-Ulcer Agents
  • Furans
  • Cimetidine
  • Ranitidine
  • Adult
  • Anti-Ulcer Agents (therapeutic use)
  • Cimetidine (therapeutic use)
  • Furans (therapeutic use)
  • Humans
  • Male
  • Ranitidine
  • Zollinger-Ellison Syndrome (drug therapy)

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