Human leukocyte interferon subtypes have different antiproliferative and antiviral activities on human cells.

Abstract

The antigrowth effects of 5 different cloned human leukocyte IFN subtypes (IFN-alpha A, B, C, D, F) and 2 molecular hybrids between them (IFN-alpha AD(Bg1II) and IFN-alpha DA(Bg1II)) were examined on 6 different human cell lines. The results indicate that the interferons sort into two distinct groups: IFN-alpha B, C and F showed comparable antiproliferative activity which was greater than that of IFN-alpha A, D, AD(Bg1II) and DA(Bg1II). The interferons could also be assigned to one of two groups on the basis of their antiviral activity. IFN-alpha A, D and AD(Bg1II) were observed to be more protective than IFN-alpha B, C and F against HSV-2 and EMCV infections, i.e. the relative antiviral efficacies of the cloned IFN subtypes were the reverse of their antiproliferative activities.

• Authors: E N Fish, K Banerjee, N Stebbing
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 112 Issue 2 Pg. 537-46 (Apr 29 1983) ISSN: 0006-291X [Print] United States
• PMID: 6303322 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antiviral Agents
• Growth Inhibitors
• Interferon Type I

Topics

• Antiviral Agents
• Cell Division (drug effects)
• Cells, Cultured
• Cytopathogenic Effect, Viral (drug effects)
• Encephalomyocarditis virus (drug effects)
• Growth Inhibitors
• Humans
• Interferon Type I (pharmacology)
• Simplexvirus (drug effects)