Abstract |
To evaluate the hemodynamic effects of dibutyryl cyclic AMP ( DBcAMP) in congestive heart failure (CHF), right-sided cardiac catheterization was performed in 11 patients with CHF, and hemodynamic variables were investigated before and after infusion of various doses of DBcAMP at a rate of 0.025 to 0.2 mg/kg/min (mean 0.14 +/- 0.077 [standard deviation]). DBcAMP reduced total systemic vascular resistance index from 3,171 +/- 1,158 to 1,880 +/- 554 dynes s cm-5 X m2 (mean +/- standard deviation) and pulmonary arterial end-diastolic pressure from 23 +/- 13 to 20 +/- 11 mm Hg, and increased cardiac index from 2.24 +/- 0.60 to 3.41 +/- 1.02 liters/min/m2. Mean arterial blood pressure decreased from 91 +/- 14 to 84 +/- 13 mm Hg, and heart rate increased from 91 +/- 16 to 99 +/- 13 beats/min. The increase in cardiac index was accompanied by a proportional decrease in total systemic vascular resistance index in all patients except 1. In 8 patients the decrease in pulmonary arterial end-diastolic pressure was accompanied by an increase or no change in the left ventricular stroke work index. In 6 patients, DBcAMP was given in incremental doses of 0.05, 0.1, and 0.2 mg/kg/min every 20 minutes, and 5 of 6 patients tolerated the full dose and showed dose-related hemodynamic changes for the incremental doses of DBcAMP. These data suggest that DBcAMP has powerful vasodilating effects on resistance vessels in patients with CHF; hence, it can be a useful vasodilating agent for treatment of CHF.
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Authors | S Matsui, E Murakami, N Takekoshi, J Emoto, M Matoba |
Journal | The American journal of cardiology
(Am J Cardiol)
Vol. 51
Issue 8
Pg. 1364-8
(May 01 1983)
ISSN: 0002-9149 [Print] United States |
PMID | 6303101
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Aged
- Blood Pressure
(drug effects)
- Bucladesine
(adverse effects, therapeutic use)
- Cardiac Output
(drug effects)
- Dose-Response Relationship, Drug
- Female
- Heart Failure
(drug therapy)
- Hemodynamics
(drug effects)
- Humans
- Male
- Middle Aged
- Stroke Volume
(drug effects)
- Vascular Resistance
(drug effects)
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