[Bone metastasis of breast cancer. Apropos of a series of 50 cases].

Abstract

Among fifty patients with bone metastases from breast cancer who were hospitalized between 1971 and 1980, 19 were given intermittent chemotherapy including both hormone-therapy (drostanolon propionate and tamoxifen) and a combination of cyclophosphamide, methotrexate, 5 FU, doxorubicin and vincristine (CMFDV). Comparison of these patients with two other groups given either miscellaneous chemotherapy programs (19 cases) or no chemotherapy (12 cases) exhibited the value of the standardized protocol, especially concerning median survival which exceeded three years (versus one year with the two other methods). Cobalt-therapy, chemotherapy and hormone-therapy in bone metastases from breast cancer are reviewed.

• Authors: F Vincent-Joyeux, D Bontoux, M Alcalay, A Daban, D Vincent
• Journal: La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris (Sem Hop) Vol. 58 Issue 48 Pg. 2827-31 (Dec 30 1982) France
• Vernacular Title: Les métastases osseuses du cancer du sein. A propos d'une série de cinquante cas.
• PMID: 6302849 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents
• Vincristine
• Doxorubicin
• Cyclophosphamide
• Fluorouracil
• Methotrexate

Topics

• Antineoplastic Agents (administration & dosage)
• Antineoplastic Combined Chemotherapy Protocols
• Bone Neoplasms (drug therapy, secondary)
• Breast Neoplasms (mortality)
• Cyclophosphamide (administration & dosage)
• Doxorubicin (administration & dosage)
• Drug Therapy, Combination
• Female
• Fluorouracil (administration & dosage)
• France
• Humans
• Methotrexate (administration & dosage)
• Vincristine (administration & dosage)