Abstract |
Neutron activation analysis was employed to determine total body calcium in 5-8 month and 15-18 month old C3H/St(Ha) and C57/BL6 (JACOBS) female mice. Ninety-nine percent of calcium is in bone and loss of calcium was used as an index of osteoporosis. Prednisolone (50 mg/kg q.d.) treatment for three months resulted in significant osteoporosis in the C3H/St(Ha) mice of both age groups but did not cause significant bone loss in the C57/BL6 (JACOBS) mice of either age group. Premarin (20 mg/kg q.d.) failed to prevent steroid accelerated osteoporosis.
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Authors | J C Robin, J L Ambrus |
Journal | Journal of medicine
(J Med)
Vol. 13
Issue 5-6
Pg. 453-63
( 1982)
ISSN: 0025-7850 [Print] United States |
PMID | 6302190
(Publication Type: Journal Article)
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Chemical References |
- Adrenal Cortex Hormones
- Estrogens
- Estrogens, Conjugated (USP)
- Prednisolone
- Calcium
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Topics |
- Adrenal Cortex Hormones
(adverse effects, therapeutic use)
- Aging
- Animals
- Calcium
(analysis)
- Estrogens
(pharmacology)
- Estrogens, Conjugated (USP)
(pharmacology)
- Female
- Mice
- Mice, Inbred C3H
- Mice, Inbred C57BL
- Osteoporosis
(chemically induced, metabolism, physiopathology)
- Prednisolone
(pharmacology)
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