HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Studies on osteoporoses. VIII. Effect of estrogen on steroid induced osteoporosis.

Abstract
Neutron activation analysis was employed to determine total body calcium in 5-8 month and 15-18 month old C3H/St(Ha) and C57/BL6 (JACOBS) female mice. Ninety-nine percent of calcium is in bone and loss of calcium was used as an index of osteoporosis. Prednisolone (50 mg/kg q.d.) treatment for three months resulted in significant osteoporosis in the C3H/St(Ha) mice of both age groups but did not cause significant bone loss in the C57/BL6 (JACOBS) mice of either age group. Premarin (20 mg/kg q.d.) failed to prevent steroid accelerated osteoporosis.
AuthorsJ C Robin, J L Ambrus
JournalJournal of medicine (J Med) Vol. 13 Issue 5-6 Pg. 453-63 ( 1982) ISSN: 0025-7850 [Print] United States
PMID6302190 (Publication Type: Journal Article)
Chemical References
  • Adrenal Cortex Hormones
  • Estrogens
  • Estrogens, Conjugated (USP)
  • Prednisolone
  • Calcium
Topics
  • Adrenal Cortex Hormones (adverse effects, therapeutic use)
  • Aging
  • Animals
  • Calcium (analysis)
  • Estrogens (pharmacology)
  • Estrogens, Conjugated (USP) (pharmacology)
  • Female
  • Mice
  • Mice, Inbred C3H
  • Mice, Inbred C57BL
  • Osteoporosis (chemically induced, metabolism, physiopathology)
  • Prednisolone (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: