Neurobehavioral actions of cannabichromene and interactions with delta 9-tetrahydrocannabinol.

Abstract

1. Neither cannabichromene (CBC) nor delta 9-tetrahydrocannabinol (THC) protected mice from electroshock-induced seizures, although THC inhibited postictal mortality. Minor effects were produced on seizure latency and duration. 2. CBC had a weak analgetic action in mice; THC had a moderate and lengthy effect, which was potentiated at 2 hr by concurrent CBC. 3. Both CBC (10-75 mg/kg, i.p.) and THC (20 mg/kg) reduced motility of mice, the THC equalling the highest dose of CBC. 4. Performance of a conditioned avoidance response was strongly impaired by THC, but not by CBC, nor did CBC combined with THC have influence on the effects of THC.

• Authors: W M Davis, N S Hatoum
• Journal: General pharmacology (Gen Pharmacol) Vol. 14 Issue 2 Pg. 247-52 ( 1983) ISSN: 0306-3623 [Print] England
• PMID: 6301931 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Analgesics
• Anticonvulsants
• Cannabinoids
• Central Nervous System Depressants
• Dronabinol
• cannabichromene

Topics

• Analgesics (pharmacology)
• Animals
• Anticonvulsants (pharmacology)
• Avoidance Learning (drug effects)
• Behavior, Animal (drug effects)
• Brain (drug effects)
• Cannabinoids (pharmacology)
• Central Nervous System Depressants (pharmacology)
• Dronabinol (pharmacology)
• Drug Interactions
• Electroshock
• Male
• Mice
• Mice, Inbred ICR
• Motor Activity (drug effects)