Mass spectrometry of N-methylsulfonylureas. A re-examination.

Abstract

Some confusion has arisen in the literature regarding the electron impact mass spectrum of N-methyltolbutamide. The situation is complicated by the thermal lability of this compound which causes the formation of the corresponding N-methylsulfonamide. We present here spectral data at relatively low probe temperatures (and without an intervening gas chromatographic system) which we believe define the mass spectrum of N-methyltolbutamide more accurately than before. Similar data are presented for the analogous N-methylacetohexamide and show a rearrangement process for both substances not reported previously for this class of compounds.

• Authors: A D Kossoy, J L Occolowitz
• Journal: Biomedical mass spectrometry (Biomed Mass Spectrom) Vol. 5 Issue 2 Pg. 123-7 (Feb 1978) ISSN: 0306-042X [Print] England
• PMID: 630049 (Publication Type: Journal Article)

Chemical References

• Sulfonylurea Compounds
• N-methyltolbutamide
• N-methylacetohexamide
• Tolbutamide
• Acetohexamide

Topics

• Acetohexamide (analogs & derivatives)
• Mass Spectrometry (methods)
• Sulfonylurea Compounds
• Tolbutamide (analogs & derivatives)