| Abstract | 68 patients were included in a prospective study of the treatment of borderline leprosy. 34 were treated with dapsone 5 mg daily, and 34 with 50 mg daily. Reversal reactions developed in 11 of those on 5 mg daily and in 3 of those on 50 mg daily. The statistically significant difference between the two treatment groups indicates that, contrary to previous teaching, dapsone given in higher dosage does not predispose patients to reversal reactions and indeed may prevent them. |
| Authors | R S Barnetson, J M Pearson, R J Rees |
| Journal | Lancet
(Lancet)
Vol. 2
Issue 7996
Pg. 1171-2
(Nov 27 1976)
ISSN: 0140-6736 ENGLAND |
| PMID | 62998
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
|
| Chemical References |
|
| Topics |
- Adolescent
- Adult
- Dapsone
(administration & dosage, therapeutic use)
- Dose-Response Relationship, Drug
- Female
- Humans
- Hypersensitivity, Delayed
(complications, prevention & control)
- Leprosy
(complications, drug therapy, immunology)
- Male
- Middle Aged
- Neuritis
(etiology)
- Prospective Studies
|
