Abstract |
Wound healing experiments were conducted in random-bred Swiss mice to determine the effect on antimicrobial surfactants and macrophage stimulators on wound measurements, histologic repair, and wound breaking strengths. In selection of mice, Sendai virus antibody-positive mice healed more slowly than did mice with no detectable titer to Sendai virus. Studies were conducted with Sendai virus-free mice that had C31G (an antimicrobial surfactant), alkyl amine oxide, zymosan, glucan, or phosphate-buffered isotonic saline solution instilled into full-thickness incised wounds. The early events in the repair process indicated a greater degree of inflammatory response comprised mainly of polymorphonuclear leukocytes with subsequent large numbers of monocytes in C31G and alkyl amine oxide-treated wounds. Although zymosan did not induce as large a number of monocytes, the degree of fibroplasia was as great as in wounds in which numbers were higher. The effect of zymosan could be blocked by the addition of N-alpha-p-tosyl- L-lysine chloromethyl ketone to wounds. Wound breaking strength 3 days after surgery was greatest for glucan-treated mice (134 +/- 37 g) whereas that in C31G-treated mice (77 +/- 31 g) was less than that of the controls (92 +/- 37 g). By day 7, there was no significant difference in breaking strength between control and glucan-treated wounds; however, C31G-treated wounds remained substantially weaker than control wounds.
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Authors | A J Kenyon, E B Michaels |
Journal | American journal of veterinary research
(Am J Vet Res)
Vol. 44
Issue 2
Pg. 340-3
(Feb 1983)
ISSN: 0002-9645 [Print] United States |
PMID | 6299147
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Antibodies, Viral
- Isotonic Solutions
- Tosyllysine Chloromethyl Ketone
- Sodium Chloride
- Zymosan
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Topics |
- Animals
- Antibodies, Viral
(analysis)
- Dermatologic Surgical Procedures
- Fibroblasts
(cytology)
- Isotonic Solutions
- Male
- Mice
- Mice, Inbred Strains
(immunology)
- Monocytes
(cytology)
- Neutrophils
(cytology)
- Parainfluenza Virus 1, Human
(immunology)
- Sodium Chloride
(pharmacology)
- Tosyllysine Chloromethyl Ketone
(pharmacology)
- Wound Healing
(drug effects)
- Wounds and Injuries
(pathology)
- Zymosan
(pharmacology)
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