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Treatment of chromomycosis with ketoconazole and 5-fluorocytosine.

Abstract
Chromomycosis is a disfiguring cutaneous mycosis that is often recalcitrant to therapy. We describe a case of chromomycosis of the lower extremities that is being successfully treated with ketoconazole and 5-fluorocytosine (5-FC) after treatment with ketoconazole alone had failed. In vitro studies showed that the drugs acted synergistically against the strain of Fonsecaea pedrosoi which was isolated from the patient's lesion.
AuthorsJ G Silber, M E Gombert, K M Green, A R Shalita
JournalJournal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 8 Issue 2 Pg. 236-8 (Feb 1983) ISSN: 0190-9622 [Print] United States
PMID6298285 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antifungal Agents
  • Imidazoles
  • Piperazines
  • Ketoconazole
Topics
  • Adult
  • Antifungal Agents (administration & dosage)
  • Chromoblastomycosis (drug therapy, pathology)
  • Drug Synergism
  • Drug Therapy, Combination
  • Humans
  • Imidazoles (administration & dosage)
  • Ketoconazole
  • Male
  • Piperazines (administration & dosage)
  • Skin (pathology)

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