Abstract |
The efficacy of ceftriaxone against group B streptococci was studied in vitro and in vivo with an infant rat model of group B streptococci bacteraemia and meningitis. Twenty-four strains demonstrated minimal inhibitory concentrations of ceftriaxone of 0 . 05-0 . 1 mg/l and minimal bactericidal concentrations of 0 . 1-0 . 4 mg/l. Four strains were selected to induce bacteraemia and meningitis in infant rats by intraperitoneal inoculation. All 45 bacteraemic animals with or without meningitis that were treated with ceftriaxone 2 mg/kg/dose every eight hours for five doses survived, while all 12 control animals died (P less than 0 . 001). When recultured 54 h after the last dose of ceftriaxone, both CSF and blood remained sterile in all treated animals. These results indicate group B streptococci to be sensitive to ceftriazone in vitro and that, in the low dosage used, ceftriaxone effectively eradicates group B streptococcal bacteraemia and meningitis in infant rats.
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Authors | D Delaplane, R Yogev, S T Shulman |
Journal | The Journal of antimicrobial chemotherapy
(J Antimicrob Chemother)
Vol. 11
Issue 1
Pg. 69-73
(Jan 1983)
ISSN: 0305-7453 [Print] England |
PMID | 6298176
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Animals
- Animals, Newborn
- Cefotaxime
(analogs & derivatives, therapeutic use)
- Ceftriaxone
- Meningitis
(drug therapy)
- Microbial Sensitivity Tests
- Rats
- Rats, Inbred Strains
- Sepsis
(drug therapy)
- Streptococcal Infections
(blood, cerebrospinal fluid, drug therapy)
- Streptococcus agalactiae
(drug effects)
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