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Ceftriaxone therapy of group B streptococcal bacteraemia and meningitis in infant rats.

Abstract
The efficacy of ceftriaxone against group B streptococci was studied in vitro and in vivo with an infant rat model of group B streptococci bacteraemia and meningitis. Twenty-four strains demonstrated minimal inhibitory concentrations of ceftriaxone of 0 . 05-0 . 1 mg/l and minimal bactericidal concentrations of 0 . 1-0 . 4 mg/l. Four strains were selected to induce bacteraemia and meningitis in infant rats by intraperitoneal inoculation. All 45 bacteraemic animals with or without meningitis that were treated with ceftriaxone 2 mg/kg/dose every eight hours for five doses survived, while all 12 control animals died (P less than 0 . 001). When recultured 54 h after the last dose of ceftriaxone, both CSF and blood remained sterile in all treated animals. These results indicate group B streptococci to be sensitive to ceftriazone in vitro and that, in the low dosage used, ceftriaxone effectively eradicates group B streptococcal bacteraemia and meningitis in infant rats.
AuthorsD Delaplane, R Yogev, S T Shulman
JournalThe Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 11 Issue 1 Pg. 69-73 (Jan 1983) ISSN: 0305-7453 [Print] England
PMID6298176 (Publication Type: Journal Article)
Chemical References
  • Ceftriaxone
  • Cefotaxime
Topics
  • Animals
  • Animals, Newborn
  • Cefotaxime (analogs & derivatives, therapeutic use)
  • Ceftriaxone
  • Meningitis (drug therapy)
  • Microbial Sensitivity Tests
  • Rats
  • Rats, Inbred Strains
  • Sepsis (drug therapy)
  • Streptococcal Infections (blood, cerebrospinal fluid, drug therapy)
  • Streptococcus agalactiae (drug effects)

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