Lymphocyte thyroid hormone receptors in obesity.

Abstract

Triiodothyronine (T3)-receptor characteristics of isolated circulating human mononuclear cells have been studied in a group of obese patients who claimed to be unable to lose weight on conventional 4.2 MJ (1000 kcal) diets. The cells of the obese patients exhibited a lower receptor capacity than those of a control group of non-obese subjects but the difference was not significant. There was a significant fall (P less than 0.01) in receptor capacity in the obese patients after 12 weeks in a 1.34 MJ (320 kcal) per d formula diet and this provides a further mechanism whereby a fall in metabolic rate takes place in response to severe dietary restriction. Some patients who also received T3 (60 micrograms/d) in addition to the formula diet showed a further fall in the receptor numbers. These findings may partly account for the previously reported resistance to thyroid hormones in obesity.

• Authors: R Moore, J N Mehrishi, A N Howard, I H Mills
• Journal: International journal of obesity (Int J Obes) Vol. 6 Issue 6 Pg. 541-8 ( 1982) England
• PMID: 6298131 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Receptors, Cell Surface
• Receptors, Thyroid Hormone
• Triiodothyronine

Topics

• Adult
• Female
• Food, Formulated
• Humans
• Lymphocytes (metabolism)
• Middle Aged
• Obesity (diet therapy, metabolism)
• Receptors, Cell Surface (analysis, metabolism)
• Receptors, Thyroid Hormone
• Triiodothyronine (analysis, metabolism)