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Trilostane in the management of Cushing's syndrome.

Abstract
Trilostane has been used to treat 6 patients with Cushing's syndrome, 4 with an adrenal adenoma and 2 with pituitary driven disease. Three patients responded clinically and biochemically to trilostane. Although effective in some cases of Cushing's syndrome, the variability of the effect of trilostane may limit its usefulness as a therapeutic agent.
AuthorsC G Semple, G H Beastall, C E Gray, J A Thomson
JournalActa endocrinologica (Acta Endocrinol (Copenh)) Vol. 102 Issue 1 Pg. 107-10 (Jan 1983) ISSN: 0001-5598 [Print] Denmark
PMID6297208 (Publication Type: Journal Article)
Chemical References
  • Dihydrotestosterone
  • Adrenocorticotropic Hormone
  • trilostane
  • Hydrocortisone
Topics
  • Adolescent
  • Adrenocorticotropic Hormone (blood)
  • Adult
  • Cushing Syndrome (drug therapy)
  • Dihydrotestosterone (analogs & derivatives, therapeutic use)
  • Drug Evaluation
  • Female
  • Humans
  • Hydrocortisone (metabolism)
  • Male
  • Middle Aged

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