Anti-inflammatory steroids without pituitary-adrenal suppression.

Abstract

When two new steroids, methyl prednisolonate and methyl 20-dihydroprednisolonate, were applied locally their anti-inflammatory activities were nearly equivalent to those of the parent compound prednisolone in the cotton pellet granuloma bioassay. However, when these two derivatives were administered systemically, their anti-inflammatory activities were weaker than those of the parent compound. Furthermore, unlike the parent compound, these new anti-inflammatory steroids did not suppress pituitary-adrenal function or cause liver glycogen depletion in rats.

• Authors: H J Lee, M R Soliman
• Journal: Science (New York, N.Y.) (Science) Vol. 215 Issue 4535 Pg. 989-91 (Feb 19 1982) ISSN: 0036-8075 [Print] United States
• PMID: 6296999 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Anti-Inflammatory Agents
• Liver Glycogen
• methyl prednisolonate
• methyl 20-dihydroprednisolonate
• Adrenocorticotropic Hormone
• Prednisolone
• Corticosterone

Topics

• Administration, Topical
• Adrenocorticotropic Hormone (blood)
• Animals
• Anti-Inflammatory Agents (pharmacology)
• Corticosterone (blood)
• Liver Glycogen (biosynthesis)
• Pituitary-Adrenal System (drug effects)
• Prednisolone (administration & dosage, analogs & derivatives, pharmacology)
• Rats