Malignant granular cell tumor. Report of a case with special reference to carcinoembryonic antigen.

A case of malignant granular cell tumor and its histochemical and electron-microscopic characteristics are reported. This case showed, in addition to the well-known distribution of this type of tumor in subcutaneous fat, mediastinum, retroperitoneum and lungs, multiple foci in the myocardium. Contrary to recent studies reporting the presence of carcinoembryonic antigen (CEA) in benign and malignant granular cell tumors, this case is CEA-negative. We suggest that the reported CEA-reactivity in this type of tumor is probably due to cross-reacting antibodies against antigens, presumably associated with lysosomes.
AuthorsJ W Steffelaar, M Nap, U J von Haelst
JournalThe American journal of surgical pathology (Am J Surg Pathol) Vol. 6 Issue 7 Pg. 665-72 (Oct 1982) ISSN: 0147-5185 [Print] UNITED STATES
PMID6295195 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Carcinoembryonic Antigen
  • Carcinoembryonic Antigen (analysis)
  • Female
  • Heart Neoplasms (immunology, pathology)
  • Humans
  • Lung Neoplasms (immunology, pathology)
  • Middle Aged
  • Neoplasms, Multiple Primary (immunology, pathology)
  • Neoplasms, Muscle Tissue (immunology, pathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: