Abstract |
The efficacy of 3 antibiotic formulations was measured in the treatment of artificially induced anaplasmosis in the early stages of an ascending parasitemia (1% to 4%) in 23 splenectomized calves. Group 1, consisting of 5 calves, served as nontreated controls. Four calves (group 2) were treated 1 time with 10 mg of oxytetracycline (T-50)/kg of body weight IM; 5 calves (group 3) were treated 3 times with 10 mg of T-50/kg IM; 5 calves (group 4) were treated 1 time with 20 mg of an experimental oxytetracycline (T-200)/kg IM; and 4 calves (group 5) were treated 1 time with 10 mg of a synthetically derived antibacterial agent, doxycycline (D-100)/kg IM. All control calves died and 1 of 4 calves died that was treated 1 time with T-50. Other deaths did not occur. All treatments were effective in moderating the infective process, but T-50 given 3 times and T-200 given 1 time were markedly more effective than T-50 and D-100 given 1 time. There appeared to be little or no difference in therapeutic efficacy between T-50 and D-100 given 1 time and between T-50 given 3 times and T-200 given 1 time.
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Authors | K L Kuttler, J E Simpson |
Journal | American journal of veterinary research
(Am J Vet Res)
Vol. 39
Issue 2
Pg. 347-9
(Feb 1978)
ISSN: 0002-9645 [Print] United States |
PMID | 629473
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Doxycycline
- Oxytetracycline
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Topics |
- Acute Disease
- Anaplasmosis
(drug therapy, microbiology)
- Animals
- Blood
(microbiology)
- Cattle
- Cattle Diseases
(drug therapy, microbiology)
- Doxycycline
(administration & dosage, therapeutic use)
- Injections, Intramuscular
- Oxytetracycline
(administration & dosage, therapeutic use)
- Splenectomy
(veterinary)
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