Anthelmintic efficacy of thenium closylate-piperazine phosphate combination tablets against Toxocara canis in pups and young dogs.

Abstract

Thenium closylate-piperazine phosphate combination tablets, tablets containing either thenium or piperazine, and control tablets (excipients only) were administered in 2 doses 5 to 7.5 hours apart to weaned pups and young dogs, in critical controlled trials to test efficacy against naturally acquired infections of Toxocara canis. In the 1st trial, the combination tablets produced a mean clearance of 94% from 18 pups. Tablets containing thenium alone showed a mean clearance of 9% from 25 pups, and tablets containing piperazine alone caused a mean clearance of 56% from 16 pups. Clearances, corrected for spontaneous worm losses observed in pups treated with the control tablets, were 90% (combination), 5% (thenium alone), and 52% (piperazine alone). In the 2nd and 3rd trials, efficacy of the combination tablet in 15 pups was 78% when corrected for worm losses in pups which had received placebo (excipient) tablets. Each component in the combination tablet contributed its full single-entity efficacy and, if in combination, synergistic effect between the components.

• Authors: R M Corwin, T A Miller
• Journal: American journal of veterinary research (Am J Vet Res) Vol. 39 Issue 2 Pg. 263-5 (Feb 1978) ISSN: 0002-9645 [Print] United States
• PMID: 629460 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Drug Combinations
• Piperazines
• Tablets
• Thiophenes

Topics

• Animals
• Ascariasis (veterinary)
• Dog Diseases (drug therapy, parasitology)
• Dogs
• Drug Combinations
• Intestines (parasitology)
• Piperazines (administration & dosage, therapeutic use)
• Tablets
• Thiophenes (administration & dosage)
• Toxocariasis (drug therapy, parasitology, veterinary)