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Doxorubicin cardiomyopathy in children with left-sided Wilms tumor.

Abstract
Two children with Wilms tumor of the left kidney experienced severe anthracycline cardiomyopathy after irradiation to the tumor bed and conventional dosage of doxorubicin. The cardiomyopathy is attributed 1) to the fact that radiation fields for left Wilms tumor include the lower portion of the heart and 2) to the interaction of doxorubicin and irradiation on cardiac muscle. It is recommended that doxorubicin dosage be sharply restricted in children with Wilms tumor of the left kidney who receive postoperative irradiation.
AuthorsD Pinkel, B Camitta, L Kun, C Howarth, T Tang
JournalMedical and pediatric oncology (Med Pediatr Oncol) Vol. 10 Issue 5 Pg. 483-8 ( 1982) ISSN: 0098-1532 [Print] United States
PMID6292680 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Doxorubicin
Topics
  • Cardiomyopathies (chemically induced, mortality)
  • Child, Preschool
  • Doxorubicin (adverse effects)
  • Female
  • Heart (drug effects, radiation effects)
  • Humans
  • Kidney Neoplasms (drug therapy, radiotherapy)
  • Lung Neoplasms (drug therapy, secondary)
  • Nephrectomy
  • Urography
  • Wilms Tumor (drug therapy, radiotherapy)

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