This paper, is concerned with fundamental and clinical studies of
ceftizoxime, a newly developed
cephalosporin derivative, in the field of obstetrics and gynecology. 1. Concentrations of
ceftizoxime after administration 1 g of
ceftizoxime by 1 hour
drip infusion were determined in genital organs in 17 patients and the exudate of pelvic dead space in 6 patients. Simulated maximal concentrations with the ratios to the simulated peak serum levels were as follows: 27.9 micrograms/g for fundal myometrium with the ratio of 48%, 36.0 micrograms/g for portio vaginalis with 62%, 17.1 micrograms/g for ovary with 29%, 15.0 micrograms/g for oviduct with 26% and 16.2 micrograms/ml for the exudate of pelvic dead space with 30%. 2. Minimal inhibitory concentrations of
ceftizoxime were determined against clinically isolated organisms from female genital
infectious diseases.
Ceftizoxime was found to have a potent in vitro activity against Gram negative bacilli; for example, 0.1 microgram/mg or low against E. coli and K. pneumoniae. Against P. aeruginosa, P. cepacia and b. fragilis,
ceftizoxime had an activity which expected to be effective in the clinical use. 3. We gave
ceftizoxime to 6 patients comprising 4 patients with puerperal
fever, 1 with
septic abortion and 1 with tubo-ovarian
abscess in daily doses of 2 to 3 g by b.i.d or t.i.d
intravenous drip infusion for 4--12 days. The results of the treatment were 'excellent' in 3 patients, 'good' in 2, and 'unevaluatable' in 1. 4. Adverse reactions occurred in 2 patients who showed eruption during the medication with
ceftizoxime. These patients had allergic histories due to
penicillin derivatives. From the above results it is concluded that
ceftizoxime is a useful
drug for
infections in obstetrical and gynecological field.