[Lung changes induced by copper sulfate. An experimental contribution to the so-called "vineyard sprayer's lung"].

Abstract

Vineyard sprayer's lung is an occupational lung disease, caused by inhalation of Bordeaux mixture (1-2% aqueous solution of copper sulfate, neutralized with hydrated lime). Experimental studies in mice after a longstanding exposition to copper sulfate aerosol showed focal accumulations of macrophages in alveoli with different cytoplasmatic inclusions, focal interstitial granuloma formation, increased formation of collagenous and elastic fibers, and increased production of surfactant phospholipids, phagocytosed by macrophages. As a conclusion of these results, copper seems to be the responsible agent for the development of lung changes, seen in vineyard sprayer's lung.

• Authors: H Eckert, S Jerochin
• Journal: Zeitschrift fur Erkrankungen der Atmungsorgane (Z Erkr Atmungsorgane) Vol. 158 Issue 3 Pg. 270-6 ( 1982) ISSN: 0303-657X [Print] Germany
• Vernacular Title: Lungenveränderungen durch Kupfersulfat. Ein experimenteller Beitrag zur sogenannten "Weinspritzerlunge" (vineyard sprayer's lung).
• PMID: 6291264 (Publication Type: English Abstract, Journal Article)

Chemical References

• Aerosols
• Pulmonary Surfactants
• Copper
• Collagen
• Elastin
• Copper Sulfate

Topics

• Aerosols
• Animals
• Collagen (metabolism)
• Copper (adverse effects)
• Copper Sulfate
• Elastin (metabolism)
• Inclusion Bodies (ultrastructure)
• Lung Diseases (chemically induced, pathology)
• Macrophages (ultrastructure)
• Mice
• Mice, Inbred Strains
• Microscopy, Electron
• Occupational Diseases (chemically induced, pathology)
• Pulmonary Alveoli (pathology)
• Pulmonary Surfactants (metabolism)