Voltage-dependent actions of short-chain polymethylene bis-trimethylammonium compounds on sympathetic ganglion neurons.

Abstract

Effects of polymethylene bis-trimethylammonium compounds (with 4-7 carbons in the polymethylene chain, C4-C7) on voltage-dependence of fast excitatory postsynaptic current (EPSC) were studied in voltage-clamped neurons of the isolated rabbit superior cervical ganglion. All these compounds shortened the EPSC decay (which remained single-exponential) and decreased (or reversed) the dependence of the EPSC decay on membrane hyperpolarization. All drugs slightly decreased the EPSC amplitude; in addition, C6 and C7 decreased their dependence on membrane hyperpolarization. It is suggested that shortening of the EPSC decay produced by ganglion-blocking agents results from their binding to the open ionic channel (channel-blocking effect). The ratio of channel-blocking activities of these drugs correlates with the well-known ratio of their ganglion-blocking activities. It is suggested that the channel-blocking activities of polymethylene bis-trimethylammonium compounds determine their ganglion-blocking activities. The model of channel-blocking action is discussed.

• Authors: A A Selyanko, V A Derkach, V I Skok
• Journal: Journal of the autonomic nervous system (J Auton Nerv Syst) Vol. 6 Issue 1 Pg. 13-21 (Jul 1982) ISSN: 0165-1838 [Print] Netherlands
• PMID: 6290558 (Publication Type: Journal Article)

Chemical References

• Bis-Trimethylammonium Compounds
• Hexamethonium Compounds
• Receptors, Cholinergic

Topics

• Animals
• Bis-Trimethylammonium Compounds (pharmacology)
• Evoked Potentials (drug effects)
• Ganglia, Sympathetic (drug effects)
• Hexamethonium Compounds (pharmacology)
• Kinetics
• Models, Neurological
• Neurons (drug effects)
• Rabbits
• Receptors, Cholinergic (drug effects)
• Synapses (drug effects)
• Synaptic Transmission (drug effects)