The effect of 13-cis-retinoic acid on dibutylnitrosamine induced polyploidy changes in mouse urothelium.

Abstract	The epithelium in the normal urinary bladder contains cells with diploid to octoploid DNA-content. The carcinogen dibutylnitrosamine (DBN), given subcutaneously in repeated doses causes a loss of polyploidy prior to cancer development. In this study the changes in polyploidy caused by DBN was followed by use of flow cytometry. 13-cis-retinoic acid did not prevent this loss of polyploidy, and did not affect the polyploidy in the normal urothelium.
Authors	J Høstmark, T Farsund
Journal	Anticancer research (Anticancer Res) 1982 May-Jun Vol. 2 Issue 3 Pg. 145-50 ISSN: 0250-7005 [Print] Greece
PMID	6289723 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Carcinogens Carrier Proteins Nitrosamines Receptors, Retinoic Acid Tretinoin dibutylnitrosamine Isotretinoin
Topics	Animals Carcinogens (toxicity) Carrier Proteins (analysis) Epithelium (drug effects) Isotretinoin Male Mice Mice, Hairless Nitrosamines (toxicity) Ploidies (drug effects) Receptors, Retinoic Acid Tretinoin (pharmacology) Urinary Bladder (drug effects, ultrastructure) Urinary Bladder Neoplasms (chemically induced)

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