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Mode of action of oxanosine, a novel nucleoside antibiotic.

Abstract
Oxanosine, a novel nucleoside, inhibits the growth of Escherichia coli K-12 on peptone agar, but not on Nutrient agar. This antibiotic activity was found to be bacteriostatic and was antagonized by guanine, guanosine, and guanylic acid. The growth of leukemia L 1210 cell was also inhibited by oxanosine, and the inhibition was reversed by guanylic acid. Oxanosine was confirmed to be a competitive inhibitor of GMP synthetase (E.C. 6.3.5.2) and the Ki value was 7.4 X 10(-4) M.
AuthorsN Yagisawa, N Shimada, T Takita, M Ishizuka, T Takeuchi, H Umezawa
JournalThe Journal of antibiotics (J Antibiot (Tokyo)) Vol. 35 Issue 6 Pg. 755-9 (Jun 1982) ISSN: 0021-8820 [Print] England
PMID6288649 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Bacterial Agents
  • Ribonucleosides
  • Guanosine
  • oxanosine
  • Guanosine Monophosphate
  • Ligases
  • Carbon-Nitrogen Ligases
  • GMP synthase (glutamine-hydrolyzing)
Topics
  • Animals
  • Anti-Bacterial Agents (pharmacology)
  • Carbon-Nitrogen Ligases
  • Escherichia coli (drug effects)
  • Guanosine (pharmacology)
  • Guanosine Monophosphate (pharmacology)
  • Leukemia L1210 (drug therapy)
  • Ligases (antagonists & inhibitors)
  • Ribonucleosides (pharmacology)

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