Beta-Endorphin. Opiate receptor-binding activity of synthetic analogs modified in the enkephalin segment in rat brain membrane and neuroblastoma x glioma hybrid cell.

Abstract	The potency of a series of synthetic analogs of beta-endorphin in inhibiting binding of [3H2-Tyr27]-beta h-endorphin to either rat brain membranes or neuroblastoma x glioma hybrid cells (NG108-15) has been determined and compared with the previously determined analgesic potency. There is a very good correlation between inhibitory potency in membranes and cells, but the correlation between analgesic potency and inhibitory potency in either membranes or cells is not as good.
Authors	R G Hammonds Jr, C H Li
Journal	International journal of peptide and protein research (Int J Pept Protein Res) Vol. 19 Issue 3 Pg. 254-8 (Mar 1982) ISSN: 0367-8377 [Print] Denmark
PMID	6288587 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Endorphins Receptors, Opioid beta-Endorphin
Topics	Animals Brain (metabolism) Cell Membrane (metabolism) Endorphins (metabolism) Glioma (metabolism) Hybrid Cells (metabolism) Kinetics Mice Neuroblastoma (metabolism) Rats Receptors, Opioid (metabolism) Structure-Activity Relationship beta-Endorphin

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