Abstract |
Pyrantel pamoate at a dose of 10 mg/kg body weight daily for 2 or 3 days was found to be more effective against Ascaris than both a regimen of bephenium hydroxynaphthoate (2.5 g base) and piperazine citrate (2-3 g) given daily for 2 days and a placebo-treated control group. The cure rates for pyrantel were about 95% compared to 90 and 20% for the other two groups respectively. None of the drug schedules was effective against the Trichuris. The bephenium/ piperazine regimen was superior to both the 2-day and 3-day courses of pyrantel pamoate against the hookworm with aggregate cure rates of 58-60% for pyrantel pamoate and 68-85% for bephenium/ piperazine. The results were better than those reported earlier in the series when a single dose of pyrantel pamoate (10 mg/kg of body weight) was used. Pyrantel pamoate was well tolerated and the drug merits further studies at higher doses, particularly against the hookworm.
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Authors | O O Kale |
Journal | African journal of medicine and medical sciences
(Afr J Med Med Sci)
1981 Mar-Jun
Vol. 10
Issue 1-2
Pg. 63-7
ISSN: 0309-3913 [Print] Nigeria |
PMID | 6287829
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
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Chemical References |
- Anthelmintics
- Bephenium Compounds
- Piperazines
- bephenium hydroxynaphthoate
- Pyrantel
- piperazine citrate
- Pyrantel Pamoate
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Topics |
- Anthelmintics
(administration & dosage, therapeutic use)
- Ascariasis
(drug therapy)
- Bephenium Compounds
(administration & dosage, therapeutic use)
- Child
- Clinical Trials as Topic
- Drug Administration Schedule
- Drug Therapy, Combination
- Hookworm Infections
(drug therapy)
- Humans
- Intestinal Diseases, Parasitic
(drug therapy)
- Nematode Infections
(drug therapy)
- Piperazines
(administration & dosage, therapeutic use)
- Pyrantel
(analogs & derivatives)
- Pyrantel Pamoate
(administration & dosage, therapeutic use)
- Trichuriasis
(drug therapy)
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