Abstract |
The pharmacokinetics of amdinocillin ( mecillinam) after multiple intravenous doses to healthy subjects are described. Assay of plasma and urine samples was carried out with a sensitive and specific high-pressure liquid chromatographic technique. A dose of 10 mg/kg of body weight was administered every 4 h for six doses. No accumulation was noted. Mean peak plasma concentrations were approximately 50 micrograms/ml, and the plasma half-life was approximately 53 min. Total plasma clearance was 4.6 ml/min per kg after the first dose, which declined slightly to 4.1 ml/min per kg after the last dose. Renal clearance remained fairly constant at approximately 2.9 ml/min per kg, or twice the creatinine clearance. The fraction excreted unchanged totaled 63% during the 4-h interval after the first dose and was nearly 70% overall. The steady-state volume of distribution was calculated to be 0.26 liter/kg. Urinary concentrations of amdinocillin were far in excess of the usual inhibitory concentrations for susceptible pathogens and were as high as 3,000 micrograms/ml. Dose of amdinocillin every 4 h provide plasma and urine concentrations which should be effective for the treatment of infections.
|
Authors | S L Barriere, J G Gambertoglio, E T Lin, J E Conte Jr |
Journal | Antimicrobial agents and chemotherapy
(Antimicrob Agents Chemother)
Vol. 21
Issue 1
Pg. 54-7
(Jan 1982)
ISSN: 0066-4804 [Print] United States |
PMID | 6282208
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
|
Chemical References |
- Anti-Bacterial Agents
- Penicillanic Acid
- Amdinocillin
|
Topics |
- Adult
- Amdinocillin
(administration & dosage, metabolism)
- Anti-Bacterial Agents
(administration & dosage, metabolism)
- Female
- Humans
- Kinetics
- Male
- Middle Aged
- Penicillanic Acid
(metabolism)
|