HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Use of intravenous Premarin in the treatment of dysfunctional uterine bleeding--a double-blind randomized control study.

Abstract
Dysfunctional uterine bleeding results from disruption of the normal sequence of ovarian cyclic hormonal stimulation of the uterine endometrium. Treatment of dysfunctional uterine bleeding previously consisted of surgical or hormonal manipulation, or both. The present study was conducted on 34 patients in a randomized double-blind fashion to evaluate the efficacy of treating dysfunctional uterine bleeding with intravenous Premarin. Bleeding stopped in 72% of patients who received intravenous Premarin and in 38% who received placebo (P = .021). Premarin was effective in terminating endometrial bleeding in patients with biopsy-proved pathology consisting of secretory, proliferative, menstrual, polypoid, or cystic hyperplasia, as well as endometritis.
AuthorsG R DeVore, O Owens, N Kase
JournalObstetrics and gynecology (Obstet Gynecol) Vol. 59 Issue 3 Pg. 285-91 (Mar 1982) ISSN: 0029-7844 [Print] United States
PMID6281704 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Estrogens, Conjugated (USP)
Topics
  • Adolescent
  • Adult
  • Biopsy
  • Blood Cell Count
  • Clinical Trials as Topic
  • Double-Blind Method
  • Endometrium (pathology)
  • Estrogens, Conjugated (USP) (administration & dosage)
  • Female
  • Humans
  • Injections, Intravenous
  • Middle Aged
  • Random Allocation
  • Uterine Hemorrhage (drug therapy)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: