HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Focal suppression and induction of hyperplasia by the bladder carcinogens butyl(4-hydroxybutyl)nitrosamine and buty(3-carboxypropyl)nitrosamine in organ-cultured rat bladder epithelium.

Abstract
The effects of the bladder carcinogens butyl(4-hydroxybutyl)nitrosamine (BBN) and butyl(3-carboxypropyl)-nitrosamine (BCPN) on proliferating transitional rat epithelium in organ culture were studied. At low to intermediate concentration ranges (0.5--2.9 mM), both compounds appeared to stimulate hyperplasia in some regions of epithelia. The major effect of both carcinogens, however, was to suppress hyperplasia in other regions of epithelia and, at higher concentrations (5--6 mM), to cause necrosis. For comparable concentrations, BBN was more effective in suppressing proliferation and causing necrosis than was BCPN.
AuthorsD H Reese, R D Friedman, W Gaffield, L K Keefer
JournalJournal of the National Cancer Institute (J Natl Cancer Inst) Vol. 60 Issue 1 Pg. 219-23 (Jan 1978) ISSN: 0027-8874 [Print] United States
PMID628018 (Publication Type: Journal Article)
Chemical References
  • Nitrosamines
  • Propionates
  • Butylhydroxybutylnitrosamine
  • butyl(3-carboxypropyl)nitrosamine
Topics
  • Animals
  • Butylhydroxybutylnitrosamine (toxicity)
  • Cell Division
  • Epithelium (drug effects, pathology)
  • Hyperplasia (chemically induced)
  • Necrosis (chemically induced)
  • Nitrosamines (toxicity)
  • Organ Culture Techniques
  • Propionates (toxicity)
  • Rats
  • Urinary Bladder (drug effects, pathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: