Combined application of metabolic myocardial arrest and general profound hypothermia in aortic valve replacement.

Abstract

To determine the value of general hypothermia in combination with magnesium-aspartate-procaine induced metabolic myocardial arrest, the surgical results of 2 similar groups of patients subjected to aortic valve replacement were compared. Metabolic arrest of the myocardium was achieved under mild hypothermic conditions in group I (71 patients) and in profound hypothermia in group II (48 patients). The operative mortality was 5.6% in group I and 4.1% in group II. There was no cardiac related with in group II. In group I two deaths were due to a low cardiac output state. In addition, 3 patients required inotropic support during the early postoperative period. Our results indicate, that magnesium-aspartate-procaine induced cardioplegia in combination with general profound hypothermia can provide effective myocardial protection during aortic valve replacement.

• Authors: W Seybold-Epting, G Fenchel, R Stunkat, H E Hoffmeister
• Journal: The Journal of cardiovascular surgery (J Cardiovasc Surg (Torino)) 1978 Jan-Feb Vol. 19 Issue 1 Pg. 1-6 ISSN: 0021-9509 [Print] Italy
• PMID: 627588 (Publication Type: Journal Article)

Topics

• Adult
• Aortic Valve Insufficiency (surgery)
• Aortic Valve Stenosis (surgery)
• Evaluation Studies as Topic
• Female
• Heart Arrest, Induced
• Heart Valve Prosthesis (adverse effects, mortality)
• Humans
• Hypothermia, Induced
• Male
• Postoperative Complications