Modification by hyperoxia of chlorphentermine- or phentermine- induced effects on newborn rat lung morphology and metabolism.

Abstract

Treatment of newborns with 20 mg/kg/day chlorphentermine orally for 1 week increased incorporation of thymidine into lung DNA without an associated change in tissue morphology or cyclic AMP levels. An increase in chlorphentermine dose to 60 mg/kg resulted in an accumulation of alveolar hypertrophic macrophages and a rise in incorporation of thymidine into lung DNA; however, cyclic AMP levels were decreased. In contrast, 20 or 60 mg/kg/day for 1 week phentermine-induced depression in the incorporation of thymidine into pulmonary DNA was accompanied by a decrease in cyclic AMP but no apparent alteration in tissue morphology. Hyperoxia did not modify the phentermine-induced changes in cyclic AMP levels and pulmonary ultrastructure. In contrast, hyperoxia altered the responsiveness of newborns to 20 mg/kg chlorphentermine as evidenced by the presence of foam cells. Data suggest that the chlorphentermine-induced increase in DNA synthesis in newborn lung seems independent of changes in cyclic AMP and tha modification of drug-induced alterations by hyperoxia may be related to the chemical structure of a compound.

• Authors: S Kacew, R Narbaitz
• Journal: Drug and chemical toxicology (Drug Chem Toxicol) Vol. 4 Issue 2 Pg. 123-32 ( 1981) ISSN: 0148-0545 [Print] United States
• PMID: 6274604 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• DNA
• Phentermine
• Cyclic AMP
• Chlorphentermine
• Oxygen
• Thymidine

Topics

• Animals
• Animals, Newborn (metabolism)
• Chlorphentermine (toxicity)
• Cyclic AMP (analysis)
• DNA (biosynthesis)
• Female
• Lung (drug effects, metabolism, pathology)
• Oxygen (pharmacology)
• Phentermine (analogs & derivatives, toxicity)
• Rats
• Rats, Inbred Strains
• Thymidine (metabolism)