Specific chromosome defect associated with human small-cell lung cancer; deletion 3p(14-23).

Abstract

A specific, acquired chromosomal abnormality (deletion 3p) has been found in at least one chromosome 3 in 100 percent of the metaphases in 12 of 12 cell lines cultured from human small-cell lung cancer tissue and in 2-day tumor culture specimens from three patients. Analysis of the shortest region of overlap shows the deletion to be 3p(14-23). This specific change was not seen in five of five lung cancer cell lines other than small-cell lung cancer or in two lymphoblastoid lines cultured from cells of small-cell lung cancer patients whose tumors had the 3p deletion.

• Authors: J Whang-Peng, C S Kao-Shan, E C Lee, P A Bunn, D N Carney, A F Gazdar, J D Minna
• Journal: Science (New York, N.Y.) (Science) Vol. 215 Issue 4529 Pg. 181-2 (Jan 08 1982) ISSN: 0036-8075 [Print] United States
• PMID: 6274023 (Publication Type: Journal Article)

Topics

• Carcinoma, Small Cell (genetics)
• Cells, Cultured
• Chromosome Deletion
• Chromosomes, Human, 1-3
• Humans
• Karyotyping
• Lung Neoplasms (genetics)