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Physiologic observations in a controlled clinical trial of the antiemetic effectiveness of 5, 10, and 15 mg of delta 9-tetrahydrocannabinol in cancer chemotherapy. Ophthalmologic implications.

Abstract
One hundred twenty patients about to receive their first treatment with potentially nauseant cancer chemotherapy were randomized to one of six antiemetic treatments: (1) no treatment; (2) placebo; (3) prochlorperazine (PCPZ), 10 mg; (4) delta 9-tetrahydrocannabinol (THC), 5 mg; (5) THC, 10 mg; (6) THC, 15 mg. Four doses of each medication were given orally at 4-hour intervals starting 2 hours before chemotherapy. A study nurse was responsible for both objective (nurse) and subjective (patient) symptom questionnaires. Serum levels were obtained at intervals for cross-reacting cannabinoids. Physiologic measurements including intraocular pressure (IOP), blood pressure, and pulmonary function were also recorded. In summary, the patients were remarkably free of adverse physiologic effects. All intraocular pressures before and after treatment were within the normal range, although a surprising statistically significant increase in IOP occurred in the group receiving 5 mg THC.
AuthorsM Levitt, A Wilson, D Bowman, S Kemel, G Krepart, V Marks, H Schipper, G Thomson, B Weinerman, R Weinerman
JournalJournal of clinical pharmacology (J Clin Pharmacol) 1981 Aug-Sep Vol. 21 Issue S1 Pg. 103S-109S ISSN: 0091-2700 [Print] England
PMID6271814 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Dronabinol
Topics
  • Antineoplastic Agents (adverse effects)
  • Clinical Trials as Topic
  • Dronabinol (blood, pharmacology, therapeutic use)
  • Female
  • Hemodynamics (drug effects)
  • Humans
  • Intraocular Pressure (drug effects)
  • Male
  • Middle Aged
  • Time Factors
  • Vomiting (drug therapy)

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