Hemopyrrole and kryptopyrrole are absent from the urine of schizophrenics and normal persons.

Abstract

We describe a method for detecting hemopyrrole and kryptopyrrole in urine, with a detection limit of 100 mug/liter (1 part in 10(7)). Urine is thoroughly extracted with methylene chloride and the extract is concentrated and examined by gas chromatography and gas chromatography-mass spectrometry. No hemopyrrole or kryptopyrrole could be detected in 52 samples, from 17 controls, 29 schizophrenics, and six persons with acute intermittent porphyria.

• Authors: P L Gendler, H A Duhan, H Rapoport
• Journal: Clinical chemistry (Clin Chem) Vol. 24 Issue 2 Pg. 230-3 (Feb 1978) ISSN: 0009-9147 [Print] England
• PMID: 627053 (Publication Type: Journal Article)

Chemical References

• Pyrroles
• hemopyrrole
• kryptopyrrole

Topics

• Chromatography, Gas
• Humans
• Mass Spectrometry
• Methods
• Porphyrias (urine)
• Pyrroles (chemical synthesis, urine)
• Schizophrenia (urine)