Impaired clearance of beta-lipotropin in uremia.

Abstract

Immunoreactive ACTH and beta-lipotropin (beta-LPH) plasma concentrations are elevated in clinically stable chronic renal failure patients on hemodialysis (LPH: patients, 271.8 +/- 35.7 fmol ml-1; normal subjects; 6.6 +/- 0.5; ACTH: patients, 56.4 +/- 15.3; normal subjects, 19.4 +/- 1.7). To begin to study the etiology of such elevated levels, the MCR, apparent volume of distribution, and fractional rate of disappearance of synthetic human ACTH and highly purified human beta-LPH were determined in two clinically stable chronic renal failure patients on hemodialysis, after bolus simultaneous injection of both peptides. Biphasic disappearance curves were obtained for beta-LPH; triphasic for ACTH. The MCR of ACTH was within the range seen in normal subjects, whereas the MCR of beta-LPH was less than one half the normal rate. The data indicate that a decrease in MCR (rather than an increase in pituitary secretory rate) may account for the higher plasma levels of beta-LPH in uremic patients.

• Authors: N Aronin, A S Liotta, B Shickmanter, G C Schussler, D T Krieger
• Journal: The Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab) Vol. 53 Issue 4 Pg. 797-800 (Oct 1981) ISSN: 0021-972X [Print] United States
• PMID: 6270175 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Lipoproteins, LDL
• Dexamethasone
• Adrenocorticotropic Hormone

Topics

• Adolescent
• Adrenocorticotropic Hormone (blood)
• Adult
• Aged
• Dexamethasone (pharmacology)
• Female
• Humans
• Lipoproteins, LDL
• Male
• Metabolic Clearance Rate
• Middle Aged
• Uremia (metabolism)