| Abstract | Between April 1976 and February 1980, serum levels of angiotensin-converting enzyme were determined in 61 cases of sarcoidosis at different stages of evolution. Cases were divided in three groups on the basis of social determinations done every 3-6 months. In the group with 46 active cases the increase in mean value of the enzyme is statistically significant compared to the control group; 30 of these (65.2%) had values higher than + 2DS. In the second group with 24 cases of non-progressive or inactive sarcoidosis the mean value was slightly higher than the normal mean value, without being statistically significant; 21 patients (87.5%) showed normal values: in the third group with 19 patients who had been treated with corticosteroids, mean value was equal to normal values; after 12 months treatment values were normal in 17 cases (89.5%). In the control group of 80 patients with a variety of pulmonary diseases other than sarcoidosis (pulmonary tuberculosis, pneumonia, pulmonary thromboembolism and primary lung cancer) only 9 cases presented values higher than the normal + 2SD (11.2% false positive). Serial determination of angiotensin-converting enzyme is a useful diagnostic parameter in sarcoidosis; especially in evaluating progression of the disease as well as the efficacy of corticosteroid treatment. |
| Authors | F Badrinas, E Buendia, M Mestre, C Sisó, G Barberá, R Garrigosa |
| Journal | Medicina clínica
(Med Clin (Barc))
Vol. 77
Issue 3
Pg. 108-14
(Jul 15 1981)
ISSN: 0025-7753 SPAIN |
| Vernacular Title | Enzima de conversíon de la angiotensina (ECA) y sarcoidosis: valor diagnóstico y pronóstico. |
| PMID | 6268903
(Publication Type: Comparative Study, English Abstract, Journal Article)
|
| Chemical References |
- Adrenal Cortex Hormones
- Peptidyl-Dipeptidase A
|
| Topics |
- Adolescent
- Adrenal Cortex Hormones
(therapeutic use)
- Adult
- Aged
- Female
- Humans
- Lung Diseases
(enzymology)
- Male
- Middle Aged
- Peptidyl-Dipeptidase A
(blood, diagnostic use)
- Prognosis
- Sarcoidosis
(diagnosis, drug therapy, enzymology)
- Time Factors
|
