[Effect of lithium preparations on the toxic effects of adrenaline].

Abstract

Experiments on rats have shown that intravenous injection of adrenaline in a dose of 0.3-0.4 mg/kg causes cardiac arrhythmia. In this case the primary arrhythmia developing immediately after adrenaline injection is followed by the recovery of sinusal rhythm which was replaced by the secondary arrhythmia. Apart from arrhythmias, there developed pulmonary edema. The animals died 2--3 minutes after adrenaline injections. Lithium chloride and lithium hydroxybutyrate removed the secondary arrhythmia and pulmonary edema. Lithium hydroxybutyrate has proved to be more effective.

• Authors: Z I Sobieva, M N Karpova, E G Kryzhanovskaia
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 91 Issue 6 Pg. 694-6 (Jun 1981) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Vliianie preparatov litiia na toksicheskie éffekty noradrenalina.
• PMID: 6268223 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Anti-Arrhythmia Agents
• Chlorides
• Hydroxybutyrates
• Organometallic Compounds
• lithium hydroxybutyrate
• Lithium
• Lithium Chloride
• Epinephrine

Topics

• Animals
• Anti-Arrhythmia Agents
• Arrhythmias, Cardiac (chemically induced, prevention & control)
• Chlorides (therapeutic use)
• Epinephrine (antagonists & inhibitors)
• Hydroxybutyrates (therapeutic use)
• Lithium (therapeutic use)
• Lithium Chloride
• Male
• Organometallic Compounds
• Pulmonary Edema (chemically induced, prevention & control)
• Rats