[Approaches to a selective chemotherapy of hepatocellular carcinoma (author's transl)].

Abstract

1. An improvement of the chemotherapy of hepatocellular carcinoma with adriamycin or 5-fluorouracil and a reduction of side effects has been achieved by intra-arterial administration of the drugs. This treatment provides a somewhat extended survival but no cure. 2. The treatment of hepatocellular carcinoma in patients by reduction of an inactive precursor of a cytocidal alkylating agent by azoreductase of the tumor showed no therapeutic effect. 3. A selective hepatocellular uptake of drugs coupled to asialoglycoproteins has been described. An application of this concept for the chemotherapy of hepatocellular carcinoma seems doubtful since a loss of binding proteins for desialylated glycoproteins during experimental hepatocarcinogenesis has been demonstrated. 4. The increased uptake of 5-fluorouridine in hepatomas after induction of a tissue-specific depletion of uridine 5'-triphosphate and cytidine 5'-triphosphate provides an effective experimental chemotherapy with limited side effects. A clinical use of this new concept for the chemotherapy of hepatocellular carcinoma may serve as a useful approach.

• Authors: J Pausch, A Holstege, D Keppler, W Gerok
• Journal: Klinische Wochenschrift (Klin Wochenschr) Vol. 59 Issue 12 Pg. 591-8 (Jun 15 1981) ISSN: 0023-2173 [Print] Germany
• Vernacular Title: Ansätze zur selektiven Chemotherapie des hepatozellulären Karzinoms.
• PMID: 6265689 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Asialoglycoproteins
• Azo Compounds
• Glycoproteins
• Pyrimidine Nucleotides
• 5-fluorouridine
• Doxorubicin
• NADH, NADPH Oxidoreductases
• Nitroreductases
• azoreductase
• Fluorouracil
• Uridine

Topics

• Antineoplastic Agents (therapeutic use)
• Asialoglycoproteins
• Azo Compounds (metabolism)
• Carcinoma, Hepatocellular (drug therapy, enzymology)
• Cell Membrane Permeability (drug effects)
• Doxorubicin (therapeutic use)
• Drug Therapy, Combination
• Enzyme Activation (drug effects)
• Fluorouracil (therapeutic use)
• Glycoproteins (metabolism)
• Humans
• Injections, Intra-Arterial
• Liver Neoplasms (drug therapy, enzymology)
• NADH, NADPH Oxidoreductases (metabolism)
• Nitroreductases
• Pyrimidine Nucleotides (antagonists & inhibitors)
• Uridine (analogs & derivatives, metabolism, therapeutic use)