In vitro activity of antimicrobial agents on Legionnaires disease bacterium.

Abstract

Six isolates of Legionnaires disease bacteria were tested for their susceptibility to 22 antimicrobial agents. The most active agent was rifampin (minimal inhibitory concentration, </=0.01 mug/ml). On the basis of minimal inhibitory concentration breakpoints that have been used to categorize susceptibility for most of these drugs, the organisms were susceptible to rifampin, cefoxitin, erythromycin, the aminoglycosides, minocycline and doxycycline, chloramphenicol, ampicillin, penicillin G, carbenicillin, colistin, and sulfamethoxazole-trimethoprim (19:1 ratio); sensitive to intermediate in susceptibility to tetracycline, methicillin, cefamandole, cephalothin, and clindamycin; and resistant to vancomycin. More clinical data must be obtained before an optimal therapeutic regimen can be recommended.

• Authors: C Thornsberry, C N Baker, L A Kirven
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 13 Issue 1 Pg. 78-80 (Jan 1978) ISSN: 0066-4804 [Print] United States
• PMID: 626494 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents

Topics

• Anti-Bacterial Agents (therapeutic use)
• In Vitro Techniques
• Legionnaires' Disease (drug therapy, microbiology)
• Microbial Sensitivity Tests
• Respiratory Tract Infections (drug therapy)