Cyclic nucleotides and aggressive behavior.

Abstract

Cyclic nucleotides, particularly cyclic AMP, have been implicated as second messengers in neuronal activity. Attempts to demonstrate an association between endogenous cAMP or cGMP levels and rodent aggressive behavior have been only partially successful. Low levels of cAMP in rodent brain appear associated with lower levels of affective aggression. Consistent with this possible relationship is our finding that the infusion of dibutyryl cAMP into rodent cerebroventricles decreases aggressive behavior. The infusion of dibutyryl cyclic GMP, conversely, facilitates shock-induced fighting in the rat.

• Authors: B Eichelman, L R Hegstrand, T McMurray, K M Kantak
• Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 14 Suppl 1 Pg. 7-12 ( 1981) ISSN: 0091-3057 [Print] United States
• PMID: 6264505 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Bucladesine
• Cyclic AMP
• Cyclic GMP

Topics

• Aggression (drug effects, physiology)
• Animals
• Brain Chemistry (drug effects)
• Bucladesine (pharmacology)
• Cyclic AMP (analysis)
• Cyclic GMP (analysis)
• Electroshock
• Humans
• Male
• Mice
• Mice, Inbred Strains
• Rats
• Rats, Inbred Strains
• Species Specificity