Rhabdoid tumor of the kidney: complete remission induced by cis-platinum and adriamycin.

Abstract

A 4-month-old male infant with Stage I rhabdoid tumor of the kidney at presentation subsequently developed pulmonary metastatic disease shortly after diagnosis and initiation of Vincristine and Actinomycin D chemotherapy. The patient was then treated with cis-platinum and Adriamycin. Within 28 days he achieved a complete remission which was maintained for 5 months. Subsequent recurrent pulmonary lesions failed to regress with radiotherapy and high-dose cyclophosphamide when used as single sequential agents. Further clinical trials with cis-platinum and Adriamycin seem warranted since prognosis with this tumor is poor and successful chemotherapy after metastatic dissemination has not been previously reported.

• Authors: M Roper, R T Parmley, W M Crist, D R Kelly, C H Hyland, M Salter
• Journal: Medical and pediatric oncology (Med Pediatr Oncol) Vol. 9 Issue 2 Pg. 175-80 ( 1981) ISSN: 0098-1532 [Print] United States
• PMID: 6262611 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Doxorubicin
• Cisplatin

Topics

• Cisplatin (administration & dosage)
• Doxorubicin (administration & dosage)
• Drug Therapy, Combination
• Humans
• Infant
• Kidney Neoplasms (drug therapy, pathology)
• Lung Neoplasms (secondary)
• Male
• Wilms Tumor (drug therapy, pathology)